isradipine

Weekly Update - Highlights include: Mayo Clinic researchers explore the relationship between low levels of Vitamin B-12 and Parkinson’s; appendix removal might or might not affect Parkinson’s risk; monkey butt research finds PD related proteins linked to inflammation; impulse control disorders and PD; Pharmaceutical News from the Annual Meeting of the American Academy of Neurology; technology targets freezing of gait; creating your own placebo effect; inspiring people with Parkinson's talk boxing, DBS and poetry; and more ...

Weekly Update - We start with why strength training should be a component of any exercise protocol for Parkinson's. Next, we find inspiration and life lessons from 6 individuals who challenge preconceived notions of Parkinson's Disease. In research news, after more than 10 years of study, a once promising drug candidate fizzles out; an interview with the doctor behind the spine tingling research featured last week; a biomarker that will bring a tear to your eye; the latest MJFox Foundation grants. Plus, we share some of our favorite updates from Parkinson's bloggers this week; Parkinson's exercise programs in the news; and ...

Major Tom to Ground Control ... this week’s report comes from  somewhere over the North Atlantic Ocean at an altitude of 36,000 feet, where we are currently testing air turbulence therapy for Parkinson’s Disease ... so apologies in advance for any and all typos. In an otherwise slow holiday week, University of Cambridge researchers are suggesting that an existing high blood pressure medication, felodipine, might be repurposed to treat Parkinson’s Disease. This study reminds me of another high blood pressure medication, isradipine, also a calcium channel blocker, which saw positive results in an animal model study 12 years ago. Since ...

In an otherwise slow holiday week, University of Cambridge researchers are suggesting that an existing high blood pressure medication might be repurposed to treat Parkinson’s Disease. Felodipine, at proportionally low doses was able to induce autophagy and clean out misfolded proteins in a mouse model of Parkinson’s. There is a lot more research needed as more PD research increasingly targets autophagy: https://www.eurekalert.org/pub_releases/2019-04/uoc-bpd041619.php This study reminds me of another high blood pressure medication, isradipine, which saw positive results in an animal model study 12 years ago. Researchers have recently completed a 3 year phase 3 study of isradipine, and these latest ...